The complete genomic sequence of Nocardia farcinica IFM 10152.
Proc Natl Acad Sci U S A, 2004/10/12;101(41):14925-30.
Ishikawa J[1], Yamashita A, Mikami Y, Hoshino Y, Kurita H, Hotta K, Shiba T, Hattori M
Affiliations
PMID: 15466710
Impact factor: 12.779
Abstract
We determined the genomic sequence of Nocardia farcinica IFM 10152, a clinical isolate, and revealed the molecular basis of its versatility. The genome consists of a single circular chromosome of 6,021,225 bp with an average G+C content of 70.8% and two plasmids of 184,027 (pNF1) and 87,093 (pNF2) bp with average G+C contents of 67.2% and 68.4%, respectively. The chromosome encoded 5,674 putative protein-coding sequences, including many candidate genes for virulence and multidrug resistance as well as secondary metabolism. Analyses of paralogous protein families suggest that gene duplications have resulted in a bacterium that can survive not only in soil environments but also in animal tissues, resulting in disease.
MeSH terms
Amino Acid Sequence; Chromosome Mapping; Chromosomes, Bacterial; Genome, Bacterial; Molecular Sequence Data; Nocardia; RNA Polymerase II; Sequence Alignment; Sequence Homology, Amino Acid
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