The complete genome sequence of Propionibacterium acnes, a commensal of human skin.
Science, 2004/7/30;305(5684):671-3.
Brüggemann H[1], Henne A, Hoster F, Liesegang H, Wiezer A, Strittmatter A, Hujer S, Dürre P, Gottschalk G
Affiliations
PMID: 15286373
Impact factor: 63.714
Abstract
Propionibacterium acnes is a major inhabitant of adult human skin, where it resides within sebaceous follicles, usually as a harmless commensal although it has been implicated in acne vulgaris formation. The entire genome sequence of this Gram-positive bacterium encodes 2333 putative genes and revealed numerous gene products involved in degrading host molecules, including sialidases, neuraminidases, endoglycoceramidases, lipases, and pore-forming factors. Surface-associated and other immunogenic factors have been identified, which might be involved in triggering acne inflammation and other P. acnes-associated diseases.
MeSH terms
Acne Vulgaris; Amino Acid Motifs; Amino Acid Sequence; Antigens, Bacterial; Bacterial Proteins; Base Sequence; Chromosomes, Bacterial; Computational Biology; Energy Metabolism; Esterases; Genes, Bacterial; Genome, Bacterial; Heat-Shock Proteins; Humans; Hydrolases; Lipase; Molecular Sequence Data; Oxidative Phosphorylation; Propionibacterium acnes; Sequence Analysis, DNA; Skin
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