1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo) induces apoptosis in human neuroblastoma cell lines.
Ann N Y Acad Sci, 2003/12;1010:304-6.
Akundi RS[1], Hüll M, Clement HW, Fiebich BL
Affiliations
PMID: 15033739
Impact factor: 6.499
Abstract
The former popular hypnotic chloral hydrate has been known to spontaneously condense with tryptamine in the body to give rise to a highly unpolar 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo) derivative. Earlier studies have revealed the relative permeability of the molecule through the body, and its ability to induce Parkinson-like symptoms in rats. In this study, we report that TaClo is a highly cytotoxic agent that leads to apoptosis in human neuroblastoma cells involving caspase-3 activation.
MeSH terms
Apoptosis; Carbolines; Caspases; Cell Line, Tumor; Cell Membrane Permeability; Humans; Neuroblastoma
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