Building predictive ADMET models for early decisions in drug discovery.
Curr Opin Drug Discov Devel, 2004/1;7(1):49-61.
Penzotti JE[1], Landrum GA, Putta S
Affiliations
PMID: 14982148
Abstract
This review discusses the current challenges facing researchers developing computational models to predict absorption, distribution, metabolism, excretion and toxicity (ADMET) for early drug discovery. The strengths and weaknesses of different modeling approaches are reviewed and a survey of recent strategies to model several key ADMET parameters, including intestinal permeability, blood-brain barrier penetration, metabolism, bioavailability and drug toxicities, is presented.
MeSH terms
Biological Availability; Biological Transport; Cation Transport Proteins; Drug Design; Drug Interactions; Drug-Related Side Effects and Adverse Reactions; Ether-A-Go-Go Potassium Channels; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Potassium Channels; Potassium Channels, Voltage-Gated
More resources
EndNote: Download