Gene expression patterns associated with recurrent chromosomal translocations in acute lymphoblastic leukemia.
Blood, 2004/2/01;103(3):1043-9.
Fine BM[1], Stanulla M, Schrappe M, Ho M, Viehmann S, Harbott J, Boxer LM
Affiliations
PMID: 14525776
Impact factor: 25.476
Abstract
We obtained a global view of gene expression in both cell lines and pediatric acute lymphoblastic leukemia (ALL) samples that harbor one of several selected chromosomal abnormalities. When the cell lines were studied alone, we found that these chromosomal abnormalities were associated with the predominant variation in transcriptional programs across the set of cell lines studied. When cell lines and clinical samples were studied together, we found that each chromosomal abnormality (TEL/AML1, BCR/ABL, or MLL abnormalities) was associated with a characteristic gene expression signature that was shared by both cell lines and clinical samples. However, BCR/ABL was associated with a much more heterogeneous pattern of expression than were TEL/AML1 and MLL abnormalities. This observation has important implications for the study of BCR/ABL ALL. In addition, we systematically identified genes whose expression was associated with TEL/AML1, BCR/ABL, or MLL abnormalities in both clinical samples and cell lines. Although some of these genes have previously been described, many have not previously been reported to be associated with one of these chromosomal abnormalities. Notably, we found that the erythropoietin receptor (EPOR) is consistently highly expressed in TEL/AML1 ALL compared with BCR/ABL or MLL.
MeSH terms
Adolescent; Base Sequence; Cell Line, Tumor; Child; Child, Preschool; Core Binding Factor Alpha 2 Subunit; DNA, Neoplasm; DNA-Binding Proteins; Female; Gene Expression; Gene Expression Profiling; Genes, abl; Histone-Lysine N-Methyltransferase; Humans; Infant; Infant, Newborn; Male; Myeloid-Lymphoid Leukemia Protein; Oncogene Proteins, Fusion; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proto-Oncogenes; Receptors, Erythropoietin; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factors; Translocation, Genetic; ETS Translocation Variant 6 Protein
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