A novel transcription factor involved in plant defense endowed with protein phosphatase activity.
EMBO J, 2003/7/01;22(13):3376-84.
Carrasco JL[1], Ancillo G, Mayda E, Vera P
Affiliations
PMID: 12839999
Impact factor: 14.012
Abstract
In plants, expression of a disease-resistance character following perception of a pathogen involves massive deployment of transcription-dependent defenses. Thus, if rapid and effective defense responses have to be achieved, it is crucial that the pathogenic signal is transduced and amplified through pre-existing signaling pathways. Reversible phosphorylation of specific transcription factors, by a concerted action of protein kinases and phosphatases, may represent a mechanism for rapid and flexible regulation of selective gene expression by environmental stimuli. Here we identified a novel DNA-binding protein from tobacco plants, designated DBP1, with protein phosphatase activity, which binds in a sequence-specific manner to a cis- acting element of a defense-related gene and participates in its transcriptional regulation. This finding helps delineate a terminal event in a signaling pathway for the selective activation of early transcription-dependent defense responses in plants, and suggests that stimulus-dependent reversible phosphorylation of regulatory proteins may occur directly in a transcription protein-DNA complex.
MeSH terms
Amino Acid Sequence; Base Sequence; Binding Sites; Cell Nucleus; DNA Primers; Gene Expression Regulation, Plant; Molecular Sequence Data; Phosphoprotein Phosphatases; Promoter Regions, Genetic; Sequence Homology, Amino Acid; Nicotiana; Transcription Factors
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