Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus faecalis.
Science, 2003/3/28;299(5615):2071-4.
Paulsen IT[1], Banerjei L, Myers GS, Nelson KE, Seshadri R, Read TD, Fouts DE, Eisen JA, Gill SR, Heidelberg JF, Tettelin H, Dodson RJ, Umayam L, Brinkac L, Beanan M, Daugherty S, DeBoy RT, Durkin S, Kolonay J, Madupu R, Nelson W, Vamathevan J, Tran B, Upton J, Hansen T, Shetty J, Khouri H, Utterback T, Radune D, Ketchum KA, Dougherty BA, Fraser CM
Affiliations
PMID: 12663927
Impact factor: 63.714
Abstract
The complete genome sequence of Enterococcus faecalis V583, a vancomycin-resistant clinical isolate, revealed that more than a quarter of the genome consists of probable mobile or foreign DNA. One of the predicted mobile elements is a previously unknown vanB vancomycin-resistance conjugative transposon. Three plasmids were identified, including two pheromone-sensing conjugative plasmids, one encoding a previously undescribed pheromone inhibitor. The apparent propensity for the incorporation of mobile elements probably contributed to the rapid acquisition and dissemination of drug resistance in the enterococci.
MeSH terms
Adhesins, Bacterial; Bacterial Adhesion; Bacterial Proteins; Biological Evolution; Carrier Proteins; Chromosomes, Bacterial; Conjugation, Genetic; Conserved Sequence; DNA Transposable Elements; Digestive System; Drug Resistance, Multiple, Bacterial; Enterococcus faecalis; Gene Transfer, Horizontal; Genome, Bacterial; Gram-Positive Bacterial Infections; Humans; Interspersed Repetitive Sequences; Lysogeny; Open Reading Frames; Oxidative Stress; Plasmids; Sequence Analysis, DNA; Synteny; Vancomycin Resistance; Virulence; Virulence Factors
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