Clinical isolates of Enterobacteriaceae producing extended-spectrum beta-lactamases: prevalence of CTX-M-3 at a hospital in China.
Antimicrob Agents Chemother, 2003/2;47(2):790-3.
Wang H[1], Kelkar S, Wu W, Chen M, Quinn JP
Affiliations
PMID: 12543694
Impact factor: 5.938
Abstract
The prevalence of extended-spectrum beta-lactamase-producing strains was demonstrated in 5 of 44 (11.4%) Escherichia coli, 17 of 43 (39.5%) Klebsiella pneumoniae, 3 of 50 (6.0%) Enterobacter cloacae, and 2 of 25 (8.0%) Citrobacter freundii strains at a teaching hospital in China. Nineteen of these 27 strains expressed CTX-M-3 beta-lactamase (pI 8.6). A subset of the clinical isolates expressing the CTX-M-3 enzyme, tested by pulsed-field gel electrophoresis, revealed multiple clones. Five isolates expressed a novel enzyme, SHV-43 (pI 8.0), which had two substitutions (Leu113Phe and Thr149Ser) compared with SHV-1.
MeSH terms
Anti-Bacterial Agents; China; Electrophoresis, Gel, Pulsed-Field; Enterobacteriaceae; Humans; Microbial Sensitivity Tests; beta-Lactamases
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