Efficacy of linezolid against methicillin-resistant or vancomycin-insensitive Staphylococcus aureus in a model of hematogenous pulmonary infection.
Antimicrob Agents Chemother, 2002/10;46(10):3288-91.
Yanagihara K[1], Kaneko Y, Sawai T, Miyazaki Y, Tsukamoto K, Hirakata Y, Tomono K, Kadota J, Tashiro T, Murata I, Kohno S
Affiliations
PMID: 12234863
Impact factor: 5.938
Abstract
We investigated the activities of linezolid, vancomycin, and teicoplanin in a murine model of hematogenous pulmonary infection with Staphylococcus aureus. Our results demonstrate that linezolid clearly reduced bacterial numbers in the methicillin-resistant S. aureus hematogenous infection model and significantly improved the survival rate of immunocompromised mice infected with vancomycin-insensitive S. aureus compared with vancomycin and teicoplanin. The pharmacokinetic profiles also reflected the effectiveness of linezolid.
MeSH terms
Acetamides; Animals; Anti-Bacterial Agents; Disease Models, Animal; Linezolid; Male; Methicillin Resistance; Mice; Oxazolidinones; Respiratory Tract Infections; Staphylococcal Infections; Staphylococcus aureus; Teicoplanin; Vancomycin
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