The genome of the natural genetic engineer Agrobacterium tumefaciens C58.
Science, 2001/12/14;294(5550):2317-23.
Wood DW[1], Setubal JC, Kaul R, Monks DE, Kitajima JP, Okura VK, Zhou Y, Chen L, Wood GE, Almeida NF Jr, Woo L, Chen Y, Paulsen IT, Eisen JA, Karp PD, Bovee D Sr, Chapman P, Clendenning J, Deatherage G, Gillet W, Grant C, Kutyavin T, Levy R, Li MJ, McClelland E, Palmieri A, Raymond C, Rouse G, Saenphimmachak C, Wu Z, Romero P, Gordon D, Zhang S, Yoo H, Tao Y, Biddle P, Jung M, Krespan W, Perry M, Gordon-Kamm B, Liao L, Kim S, Hendrick C, Zhao ZY, Dolan M, Chumley F, Tingey SV, Tomb JF, Gordon MP, Olson MV, Nester EW
Affiliations
PMID: 11743193
Impact factor: 63.714
Abstract
The 5.67-megabase genome of the plant pathogen Agrobacterium tumefaciens C58 consists of a circular chromosome, a linear chromosome, and two plasmids. Extensive orthology and nucleotide colinearity between the genomes of A. tumefaciens and the plant symbiont Sinorhizobium meliloti suggest a recent evolutionary divergence. Their similarities include metabolic, transport, and regulatory systems that promote survival in the highly competitive rhizosphere; differences are apparent in their genome structure and virulence gene complement. Availability of the A. tumefaciens sequence will facilitate investigations into the molecular basis of pathogenesis and the evolutionary divergence of pathogenic and symbiotic lifestyles.
MeSH terms
Agrobacterium tumefaciens; Bacterial Adhesion; Bacterial Proteins; Carrier Proteins; Chromosomes, Bacterial; Conjugation, Genetic; DNA Replication; Genes, Bacterial; Genes, Regulator; Genome, Bacterial; Membrane Proteins; Molecular Sequence Data; Phylogeny; Plants; Plasmids; Replicon; Rhizobiaceae; Sequence Analysis, DNA; Sinorhizobium meliloti; Symbiosis; Virulence
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