Evolution of TEM-related extended-spectrum beta-lactamases in Korea.
Antimicrob Agents Chemother, 2001/12;45(12):3651-3.
Pai H[1], Lee HJ, Choi EH, Kim J, Jacoby GA
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PMID: 11709362
Impact factor: 5.938
Abstract
TEM-52, differing from TEM-1 by having the substitutions Glu-104-->Lys, Met-182-->Thr, and Gly-238-->Ser, has previously been described as the most prevalent extended-spectrum beta-lactamase (ESBL) in Korea. In a further survey, we discovered the ESBLs TEM-15, which is like TEM-52 but lacks the substitution at residue 182, and TEM-88, which is like TEM-52 with an additional Gly-196-->Asp substitution. TEM-88 retained the activity of TEM-52 against moxalactam. Otherwise, the kinetic properties of the three ESBLs failed to show an advantage to this evolution.
MeSH terms
Anti-Bacterial Agents; Biological Evolution; Escherichia coli; Genes, Bacterial; Kinetics; Klebsiella pneumoniae; Korea; Microbial Sensitivity Tests; Models, Molecular; Molecular Sequence Data; Plasmids; beta-Lactamases; beta-Lactams
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