Cloning and biochemical characterization of FOX-5, an AmpC-type plasmid-encoded beta-lactamase from a New York City Klebsiella pneumoniae clinical isolate.
Antimicrob Agents Chemother, 2001/11;45(11):3189-94.
Queenan AM[1], Jenkins S, Bush K
Affiliations
PMID: 11600376
Impact factor: 5.938
Abstract
Klebsiella pneumoniae 5064, isolated in New York, carried plasmid-mediated resistance to multiple beta-lactams and was unresponsive to clavulanic acid. The beta-lactamase gene responsible for cephalosporin resistance encoded FOX-5, with 96 to 97% amino acid identities to other members of the FOX family of beta-lactamases. The bla(FOX-5) coding region was located next to a transposase gene from the Aeromonas salmonicida insertion element ISAS2.
MeSH terms
Aged; Aged, 80 and over; Amino Acid Sequence; Anti-Bacterial Agents; Clavulanic Acid; Cloning, Molecular; Enzyme Inhibitors; Female; Humans; Isoelectric Focusing; Klebsiella Infections; Klebsiella pneumoniae; Molecular Sequence Data; New York City; Plasmids; Substrate Specificity; beta-Lactam Resistance; beta-Lactamase Inhibitors; beta-Lactamases
More resources
Full text:
Europe PubMed Central; PubMed Central
EndNote: Download