Identification of a plasmid encoding SHV-12, TEM-1, and a variant of IMP-2 metallo-beta-lactamase, IMP-8, from a clinical isolate of Klebsiella pneumoniae.
Antimicrob Agents Chemother, 2001/8;45(8):2368-71.
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PMID: 11451699
Impact factor: 5.938
Abstract
A multidrug-resistant plasmid encoding TEM-1, SHV-12, and a variant of IMP-2 metallo-beta-lactamase, designated IMP-8, was identified from a clinical isolate of Klebsiella pneumoniae. There are four nucleotide differences between bla(IMP-2) and bla(IMP-8), resulting in two amino acid differences. bla(IMP-8) was also found to be carried by an integron-borne gene cassette similar to the bla(IMP-2) cassette.
MeSH terms
Amino Acid Sequence; Bacterial Proteins; Base Sequence; Cloning, Molecular; Drug Resistance, Microbial; Drug Resistance, Multiple; Humans; Isoelectric Focusing; Klebsiella pneumoniae; Microbial Sensitivity Tests; Molecular Sequence Data; Plasmids; beta-Lactamases
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