Biosynthesis of fatty acids in the docosahexaenoic acid-producing bacterium Moritella marina strain MP-1.
Biochem Soc Trans, 2000/12;28(6):943-5.
Morita N[1], Tanaka M, Okuyama H
Affiliations
PMID: 11171265
Impact factor: 4.919
Abstract
We have isolated the fatty acid biosynthetic (fab) gene cluster taking part in the synthesis of middle-chain fatty acids and a genomic segment which was homologous with the eicosapentaenoic acid-biosynthetic gene cluster from the docosahexaenoic acid (DHA)-producing bacterium Moritella marina strain MP-1. This segment was presumed to include the DHA-biosynthetic gene cluster of M. marina strain MP-1. When M. marina strain MP-1 was cultured in medium containing cerulenin, a fatty acid synthesis inhibitor, decreases in levels of middle-chain fatty acids and remarkable increases in levels of DHA were observed. These results suggest that the synthesis of middle-chain fatty acids works independently of the synthesis of DHA.
MeSH terms
Bacillus subtilis; Cerulenin; Docosahexaenoic Acids; Escherichia coli; Fatty Acids; Gammaproteobacteria; Molecular Sequence Data; Multigene Family; Open Reading Frames
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