IS1675, a novel lactococcal insertion element, forms a transposon-like structure including the lacticin 481 lantibiotic operon.
J Bacteriol, 2000/10;182(19):5600-5.
Dufour A[1], Rincé A, Uguen P, Le Pennec JP
Affiliations
PMID: 10986268
Impact factor: 3.476
Abstract
Two copies of IS1675, a novel lactococcal insertion element from the IS4 family, are present on a 70-kb plasmid, where they frame the lantibiotic lacticin 481 operon. The whole structure could be a composite transposon designated Tn5721. This study shows that the lacticin 481 operon does not include any regulatory gene and provides a new example of a transposon-associated bacteriocin determinant. We identified five other IS1675 copies not associated with the lacticin 481 operon. The conservation of IS1675 flanking sequences suggested a 24-bp target site.
MeSH terms
Amino Acid Sequence; Anti-Bacterial Agents; Bacterial Proteins; Bacteriocins; Base Sequence; DNA Transposable Elements; DNA, Bacterial; Genes, Bacterial; Lactococcus lactis; Molecular Sequence Data; Operon; Sequence Analysis, DNA
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