Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6.
Science, 1999/10/15;286(5439):525-8.
Yang D[1], Chertov O, Bykovskaia SN, Chen Q, Buffo MJ, Shogan J, Anderson M, Schröder JM, Wang JM, Howard OM, Oppenheim JJ
Affiliations
PMID: 10521347
Impact factor: 63.714
Abstract
Defensins contribute to host defense by disrupting the cytoplasmic membrane of microorganisms. This report shows that human beta-defensins are also chemotactic for immature dendritic cells and memory T cells. Human beta-defensin was selectively chemotactic for cells stably transfected to express human CCR6, a chemokine receptor preferentially expressed by immature dendritic cells and memory T cells. The beta-defensin-induced chemotaxis was sensitive to pertussis toxin and inhibited by antibodies to CCR6. The binding of iodinated LARC, the chemokine ligand for CCR6, to CCR6-transfected cells was competitively displaced by beta-defensin. Thus, beta-defensins may promote adaptive immune responses by recruiting dendritic and T cells to the site of microbial invasion through interaction with CCR6.
MeSH terms
Antibodies; Binding, Competitive; Cell Line; Chemokine CCL20; Chemokines, CC; Chemotaxis; Chemotaxis, Leukocyte; Defensins; Dendritic Cells; Humans; Immunity, Active; Immunity, Innate; Immunologic Memory; Macrophage Inflammatory Proteins; Pertussis Toxin; Proteins; Receptors, CCR6; Receptors, Chemokine; Recombinant Proteins; T-Lymphocyte Subsets; Transfection; Virulence Factors, Bordetella; beta-Defensins
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