An SHV-derived extended-spectrum beta-lactamase in Pseudomonas aeruginosa.
Antimicrob Agents Chemother, 1999/5;43(5):1281-4.
Naas T[1], Philippon L, Poirel L, Ronco E, Nordmann P
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PMID: 10223953
Impact factor: 5.938
Abstract
A clinical isolate of Pseudomonas aeruginosa RP-1 produced the extended-spectrum beta-lactamase (ESBL) SHV-2a. Its gene was expressed from a composite promoter made of the -35 region derived from the left inverted repeat of IS26 and the -10 region from the blaSHV-2a promoter itself. The DNA sequences immediately surrounding blaSHV-2a were homologous to plasmid pMPA2a from Klebsiella pneumoniae KpZU-3, while further away and 3' to the blaSHV-2a gene, a sequence corresponding to the left end of Tn1721 was detected, thus indicating a likely enterobacterial origin of this ESBL gene.
MeSH terms
Base Sequence; Genes, Bacterial; Klebsiella pneumoniae; Molecular Sequence Data; Plasmids; Pseudomonas aeruginosa; Sequence Homology, Nucleic Acid; beta-Lactamases
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