Full name: TNF superfamily member 15

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: TL1; TL1A; TNLG1B; VEGI; VEGI192A

Summary: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

Expression: Broad expression in duodenum (RPKM 4.3), urinary bladder (RPKM 3.6) and 17 other tissues

Gene size: 21405bp

Exon count: 4