Full name: centrosomal protein 170

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: FAM68A; KAB; KIAA0470

Summary: The product of this gene is a component of the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. During interphase, the encoded protein localizes to the sub-distal appendages of mature centrioles, which are microtubule-based structures thought to help organize centrosomes. During mitosis, the protein associates with spindle microtubules near the centrosomes. The protein interacts with and is phosphorylated by polo-like kinase 1, and functions in maintaining microtubule organization and cell morphology. The human genome contains a putative transcribed pseudogene. Several alternatively spliced transcript variants of this gene have been found, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

Expression: Broad expression in brain (RPKM 12.9), testis (RPKM 11.4) and 23 other tissues

Gene size: 131358bp

Exon count: 23