Full name: DAZ associated protein 2

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: PRTB

Summary: This gene encodes a proline-rich protein which interacts with the deleted in azoospermia (DAZ) and the deleted in azoospermia-like gene through the DAZ-like repeats. This protein also interacts with the transforming growth factor-beta signaling molecule SARA (Smad anchor for receptor activation), eukaryotic initiation factor 4G, and an E3 ubiquitinase that regulates its stability in splicing factor containing nuclear speckles. The encoded protein may function in various biological and pathological processes including spermatogenesis, cell signaling and transcription regulation, formation of stress granules during translation arrest, RNA splicing, and pathogenesis of multiple myeloma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

Expression: Ubiquitous expression in bone marrow (RPKM 168.5), thyroid (RPKM 98.1) and 25 other tissues

Gene size: 7892bp

Exon count: 5