Full name: dedicator of cytokinesis 4

Gene type: protein coding

RefSeq status: REVIEWED

Summary: This gene is a member of the dedicator of cytokinesis (DOCK) family and encodes a protein with a DHR-1 (CZH-1) domain, a DHR-2 (CZH-2) domain and an SH3 domain. This membrane-associated, cytoplasmic protein functions as a guanine nucleotide exchange factor and is involved in regulation of adherens junctions between cells. Mutations in this gene have been associated with ovarian, prostate, glioma, and colorectal cancers. Alternatively spliced variants which encode different protein isoforms have been described, but only one has been fully characterized. [provided by RefSeq, Jul 2008]

Expression: Broad expression in lung (RPKM 9.6), brain (RPKM 9.0) and 23 other tissues

Gene size: 480290bp

Exon count: 55