Full name: apoptosis associated tyrosine kinase

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: AATYK; AATYK1; LMR1; LMTK1; PPP1R77; p35BP

Summary: The protein encoded by this gene contains a tyrosine kinase domain at the N-terminus and a proline-rich domain at the C-terminus. This gene is induced during apoptosis, and expression of this gene may be a necessary pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells. This gene has been shown to produce neuronal differentiation in a neuroblastoma cell line. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

Expression: Biased expression in brain (RPKM 12.1), duodenum (RPKM 7.0) and 11 other tissues

Gene size: 48927bp

Exon count: 15