Full name: ring finger protein 14

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: ARA54; HFB30; HRIHFB2038; TRIAD2

Summary: The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Six alternatively spliced transcript variants encoding two distinct isoforms have been reported. [provided by RefSeq, Jan 2011]

Expression: Ubiquitous expression in testis (RPKM 10.0), thyroid (RPKM 8.1) and 25 other tissues

Gene size: 40956bp

Exon count: 13