BABAM2 BRISC and BRCA1 A complex member 2 [ Homo sapiens (human) ] - Gene - Data resources

9577

BABAM2 BRISC and BRCA1 A complex member 2 [ Homo sapiens (human) ]
Source: NCBI Gene (ID 9577)

Symbol: BABAM2

Full name: BRISC and BRCA1 A complex member 2

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: BRCC4; BRCC45; BRE

Summary: This gene encodes an anti-apoptotic, death receptor-associated protein that interacts with tumor necrosis factor-receptor-1. The encoded protein acts as an adapter in several protein complexes, including the BRCA1-A complex and the BRISC complex. The BRCA1-A complex possesses ubiquitinase activity and targets sites of double strand DNA breaks, while the BRISC complex exhibits deubiquitinase activity and is involved in mitotic spindle assembly. This gene is upregulated in several types of cancer. [provided by RefSeq, Jun 2016]

Expression: Ubiquitous expression in adrenal (RPKM 43.3), heart (RPKM 14.4) and 24 other tissues

Orthologs: mouse

Gene size: 450193bp

Exon count: 16