Full name: eukaryotic translation elongation factor 1 epsilon 1

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: AIMP3; P18

Summary: This gene encodes a multifunctional protein that localizes to both the cytoplasm and nucleus. In the cytoplasm, the encoded protein is an auxiliary component of the macromolecular aminoacyl-tRNA synthase complex. However, its mouse homolog has been shown to translocate to the nucleus in response to DNA damage, and it plays a positive role in ATM/ATR-mediated p53 activation. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream MUTED (muted homolog) gene. An EEF1E1-related pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2010]

Expression: Ubiquitous expression in testis (RPKM 14.5), kidney (RPKM 11.4) and 25 other tissues

Gene size: 29189bp

Exon count: 5