Full name: cell adhesion molecule 3

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: BIgR; Igsf4b; Necl-1; Necl1; SynCAM3; Tsll1

Summary: Enables protein homodimerization activity. Involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules and homophilic cell adhesion via plasma membrane adhesion molecules. Acts upstream of or within protein localization. Located in cell-cell junction and parallel fiber to Purkinje cell synapse. Is integral component of presynaptic membrane. Is expressed in several structures, including intestine; liver; nervous system; neural retina; and olfactory epithelium. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease. Orthologous to human CADM3 (cell adhesion molecule 3). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Biased expression in cerebellum adult (RPKM 149.0), frontal lobe adult (RPKM 64.2) and 7 other tissues

Gene size: 36247bp

Exon count: 10