Full name: cytochrome c oxidase subunit 5A

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: COX; COX-VA; MC4DN20; VA

Summary: Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer of proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit Va of the human mitochondrial respiratory chain enzyme. A pseudogene COX5AP1 has been found in chromosome 14q22. [provided by RefSeq, Jul 2008]

Expression: Broad expression in heart (RPKM 144.5), colon (RPKM 144.4) and 25 other tissues

Gene size: 18283bp

Exon count: 5