Full name: charged multivesicular body protein 4C

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: SNF7-3; Shax3; VPS32C

Summary: CHMP4C belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]

Expression: Broad expression in duodenum (RPKM 19.0), small intestine (RPKM 14.8) and 19 other tissues

Gene size: 27068bp

Exon count: 5