Full name: leucine rich glioma inactivated 1

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: ADLTE; ADPAEF; ADPEAF; EPITEMPIN; EPT; ETL1; IB1099

Summary: This gene encodes a member of the secreted leucine-rich repeat (LRR) superfamily and shares homology with members of the SLIT protein family. The encoded protein may regulate the activity of voltage-gated potassium channels and may be involved in neuronal growth regulation and cell survival. This gene is rearranged as a result of translocations in glioblastoma cell lines, and it is frequently down-regulated or rearranged in malignant gliomas. Mutations in this gene result in autosomal dominant lateral temporal epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Expression: Biased expression in brain (RPKM 13.8), esophagus (RPKM 1.7) and 3 other tissues

Gene size: 40224bp

Exon count: 8