Full name: Cdk5 and Abl enzyme substrate 1

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: CABL1; CABLES; HsT2563; IK3-1

Summary: This gene encodes a protein involved in regulation of the cell cycle through interactions with several cyclin-dependent kinases. One study (PMID: 16177568) reported aberrant splicing of transcripts from this gene which results in removal of the cyclin binding domain only in human cancer cells, and reduction in gene expression was shown in colorectal cancers (PMID: 17982127).Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Expression: Broad expression in lung (RPKM 9.3), fat (RPKM 7.7) and 24 other tissues

Gene size: 125907bp

Exon count: 12