Full name: eukaryotic translation initiation factor 2 subunit beta

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: EIF2; EIF2B; EIF2beta; PPP1R67; eIF-2-beta

Summary: Eukaryotic translation initiation factor 2 (EIF-2) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. EIF-2 is composed of three subunits, alpha, beta, and gamma, with the protein encoded by this gene representing the beta subunit. The beta subunit catalyzes the exchange of GDP for GTP, which recycles the EIF-2 complex for another round of initiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

Expression: Ubiquitous expression in placenta (RPKM 24.2), thyroid (RPKM 22.6) and 25 other tissues

Gene size: 23935bp

Exon count: 9