Full name: histone deacetylase 3

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: HD3; KDAC3; RPD3; RPD3-2

Summary: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq, Jul 2008]

Expression: Ubiquitous expression in lymph node (RPKM 21.1), adrenal (RPKM 20.9) and 25 other tissues

Gene size: 15969bp

Exon count: 15