Full name: TNFRSF1A associated via death domain

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: Hs.89862

Summary: The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. [provided by RefSeq, Jul 2008]

Expression: Ubiquitous expression in stomach (RPKM 7.8), spleen (RPKM 7.4) and 25 other tissues

Gene size: 5725bp

Exon count: 5