Full name: dynein light chain LC8-type 1

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: DLC1; DLC8; DNCL1; DNCLC1; LC8; LC8a; PIN; hdlc1

Summary: Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]

Expression: Ubiquitous expression in brain (RPKM 141.7), esophagus (RPKM 133.4) and 25 other tissues

Gene size: 28652bp

Exon count: 4