Full name: src kinase associated phosphoprotein 1

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: HEL-S-81p; SCAP1; SKAP55

Summary: This gene encodes a T cell adaptor protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adaptor protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins. [provided by RefSeq, Jul 2008]

Expression: Broad expression in lymph node (RPKM 9.4), spleen (RPKM 4.5) and 17 other tissues

Gene size: 311620bp

Exon count: 19