Full name: CBFA2/RUNX1 partner transcriptional co-repressor 3

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: ETO2; MTG16; MTGR2; RUNX1T3; ZMYND4

Summary: This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(16;21)(q24;q22) translocation is one of the less common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. This gene is also a putative breast tumor suppressor. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]

Expression: Broad expression in spleen (RPKM 6.2), lymph node (RPKM 3.7) and 24 other tissues

Gene size: 102350bp

Exon count: 14