Full name: RUNX family transcription factor 1

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: AML1; AML1-EVI-1; AMLCR1; CBF2alpha; CBFA2; EVI-1; PEBP2aB; PEBP2alpha

Summary: Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Expression: Broad expression in appendix (RPKM 7.9), bone marrow (RPKM 7.3) and 24 other tissues

Gene size: 261502bp

Exon count: 12