Full name: alkylglycerone phosphate synthase

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: ADAP-S; ADAS; ADHAPS; ADPS; ALDHPSY; RCDP3

Summary: This gene is a member of the FAD-binding oxidoreductase/transferase type 4 family. It encodes a protein that catalyzes the second step of ether lipid biosynthesis in which acyl-dihydroxyacetonephosphate (DHAP) is converted to alkyl-DHAP by the addition of a long chain alcohol and the removal of a long-chain acid anion. The protein is localized to the inner aspect of the peroxisomal membrane and requires FAD as a cofactor. Mutations in this gene have been associated with rhizomelic chondrodysplasia punctata, type 3 and Zellweger syndrome. [provided by RefSeq, Jul 2008]

Expression: Ubiquitous expression in colon (RPKM 7.8), endometrium (RPKM 6.7) and 25 other tissues

Gene size: 151062bp

Exon count: 22