Full name: cingulin like 1

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: JACOP; PCING

Summary: This gene encodes a member of the cingulin family. The encoded protein localizes to both adherens and tight cell-cell junctions and mediates junction assembly and maintenance by regulating the activity of the small GTPases RhoA and Rac1. Heterozygous chromosomal rearrangements resulting in association of the promoter for this gene with the aromatase gene are a cause of aromatase excess syndrome. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Nov 2011]

Expression: Broad expression in kidney (RPKM 42.7), prostate (RPKM 13.0) and 15 other tissues

Gene size: 174213bp

Exon count: 28