Full name: frizzled class receptor 6

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: FZ-6; FZ6; HFZ6; NDNC1; NDNC10

Summary: This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.[provided by RefSeq, Aug 2011]

Expression: Ubiquitous expression in thyroid (RPKM 15.4), lung (RPKM 14.1) and 25 other tissues

Gene size: 34373bp

Exon count: 8