TRRAP transformation/transcription domain associated protein [ Homo sapiens (human) ] - Gene - Data resources

8295

TRRAP transformation/transcription domain associated protein [ Homo sapiens (human) ]
Source: NCBI Gene (ID 8295)

Symbol: TRRAP

Full name: transformation/transcription domain associated protein

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: DEDDFA; DFNA75; PAF350/400; PAF400; STAF40; TR-AP; Tra1

Summary: This gene encodes a large multidomain protein of the phosphoinositide 3-kinase-related kinases (PIKK) family. The encoded protein is a common component of many histone acetyltransferase (HAT) complexes and plays a role in transcription and DNA repair by recruiting HAT complexes to chromatin. Deregulation of this gene may play a role in several types of cancer including glioblastoma multiforme. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

Expression: Ubiquitous expression in testis (RPKM 10.2), ovary (RPKM 8.3) and 25 other tissues

Orthologs: mouse

Gene size: 134710bp

Exon count: 73