Full name: vacuole membrane protein 1

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: EPG3; TANGO5; TMEM49

Summary: This gene encodes a transmembrane protein that plays a key regulatory role in the process of autophagy. The ectopic overexpression of the encoded protein in cultured cells triggers autophagy even under nutrient-rich conditions. This gene is overexpressed in pancreatitis affected acinar cells where the encoded protein mediates sequestration and degradation of potentially deleterious activated zymogen granules in a process termed, zymophagy. [provided by RefSeq, Jul 2016]

Expression: Ubiquitous expression in gall bladder (RPKM 60.7), appendix (RPKM 49.2) and 25 other tissues

Gene size: 134602bp

Exon count: 13