Full name: cyclin dependent kinase 2 associated protein 1

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: DOC1; DORC1; ST19; doc-1; p12DOC-1

Summary: The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]

Expression: Ubiquitous expression in brain (RPKM 57.9), endometrium (RPKM 35.8) and 25 other tissues

Gene size: 11265bp

Exon count: 8