Full name: negative elongation factor complex member E

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: D6S45; NELF-E; RD; RDBP; RDP

Summary: The protein encoded by this gene is part of a complex termed negative elongation factor (NELF) which represses RNA polymerase II transcript elongation. This protein bears similarity to nuclear RNA-binding proteins; however, it has not been demonstrated that this protein binds RNA. The protein contains a tract of alternating basic and acidic residues, largely arginine (R) and aspartic acid (D). The gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. [provided by RefSeq, Jul 2008]

Expression: Ubiquitous expression in testis (RPKM 52.1), ovary (RPKM 20.1) and 25 other tissues

Gene size: 6885bp

Exon count: 11