Full name: ChaC glutathione specific gamma-glutamylcyclotransferase 1

Gene type: protein coding

RefSeq status: REVIEWED

Summary: This gene encodes a member of the gamma-glutamylcyclotransferase family of proteins. The encoded protein has been shown to promote neuronal differentiation by deglycination of the Notch receptor, which prevents receptor maturation and inhibits Notch signaling. This protein may also play a role in the unfolded protein response, and in regulation of glutathione levels and oxidative balance in the cell. Elevated expression of this gene may indicate increased risk of cancer recurrence among breast and ovarian cancer patients. [provided by RefSeq, Sep 2016]

Expression: Broad expression in esophagus (RPKM 2.7), pancreas (RPKM 2.0) and 19 other tissues

Gene size: 3042bp

Exon count: 3