Full name: tRNA splicing endonuclease subunit 34

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: LENG5; PCH2C; SEN34; SEN34L

Summary: This gene encodes a catalytic subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns from precursor tRNAs. The endonuclease complex is also associated with a pre-mRNA 3-prime end processing factor. A mutation in this gene results in the neurological disorder pontocerebellar hypoplasia type 2. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Oct 2009]

Expression: Ubiquitous expression in testis (RPKM 9.1), prostate (RPKM 8.4) and 25 other tissues

Gene size: 5092bp

Exon count: 8