Full name: coronin 2A

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: CLIPINB; IR10; WDR2

Summary: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 5 WD repeats, and has a structural similarity with actin-binding proteins: the D. discoideum coronin and the human p57 protein, suggesting that this protein may also be an actin-binding protein that regulates cell motility. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]

Expression: Broad expression in small intestine (RPKM 15.5), duodenum (RPKM 14.7) and 16 other tissues

Gene size: 71663bp

Exon count: 14