Full name: ATP-binding cassette, sub-family A (ABC1), member 12

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: 4832428G11Rik; 4833417A11Rik

Summary: Predicted to enable ATPase-coupled transmembrane transporter activity; apolipoprotein A-I receptor binding activity; and lipid transporter activity. Involved in several processes, including corneocyte desquamation; positive regulation of intracellular lipid transport; and regulation of insulin secretion involved in cellular response to glucose stimulus. Acts upstream of or within several processes, including positive regulation of cholesterol efflux; positive regulation of protein localization to cell surface; and skin development. Located in cytosol. Is expressed in adrenal gland; epidermis; and gland. Used to study autosomal recessive congenital ichthyosis 4B. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 1; autosomal recessive congenital ichthyosis 4A; and autosomal recessive congenital ichthyosis 4B. Orthologous to human ABCA12 (ATP binding cassette subfamily A member 12). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Low expression observed in reference dataset

Gene size: 171821bp

Exon count: 53