Full name: von Willebrand factor

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: F8VWF; VWD

Summary: This gene encodes a glycoprotein involved in hemostasis. The encoded preproprotein is proteolytically processed following assembly into large multimeric complexes. These complexes function in the adhesion of platelets to sites of vascular injury and the transport of various proteins in the blood. Mutations in this gene result in von Willebrand disease, an inherited bleeding disorder. An unprocessed pseudogene has been found on chromosome 22. [provided by RefSeq, Oct 2015]

Expression: Broad expression in fat (RPKM 93.4), lung (RPKM 58.7) and 16 other tissues

Gene size: 175794bp

Exon count: 53