Full name: autophagy related 7

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: 1810013K23Rik; Agp7; Apg7l; Atg7l; Gm21553

Summary: This gene encodes an E1-like activating enzyme that is essential for autophagy and cytoplasmic to vacuole transport. The encoded protein is also thought to modulate p53-dependent cell cycle pathways during prolonged metabolic stress. It has been associated with multiple functions, including axon membrane trafficking, axonal homeostasis, mitophagy, adipose differentiation, and hematopoietic stem cell maintenance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Expression: Ubiquitous expression in subcutaneous fat pad adult (RPKM 13.1), testis adult (RPKM 12.7) and 28 other tissues

Gene size: 217491bp

Exon count: 24